A case-control study was conducted on 91 cases with histologically-confirmed borderline ovarian tumours and 237 control subjects in hospital for acute non-gynaecological, hormonal or neoplastic disease. Women reporting three or more births, compared to nulliparae, had a relative risk (RR) estimate of 0.6, but this finding was not statistically significant (95% confidence interval (CI): 0.2-1.4). The risk of borderline tumours increased, although not significantly, with later age at first birth: compared to women reporting first birth at age 24 or before, the RRs were 1.3 and 1.7 in those reporting respectively their first birth at age 25-29 and 30 years or more. No significant relationship emerged between borderline ovarian cancer and age at menarche, menopausal status and lifelong menstrual pattern. Cases tended to report a later age at menopause than controls, but the trend in risk was not statistically significant. Nine cases (9.9%) and 68 controls (24.9%) reported oral contraceptive use: compared with never users the multivariate RR for ever users was 0.3, and the risk dropped with duration of use to 0.2 in users for two years or more (chi 2 (1) trend = 12.70, p less than 0.001). This study provides epidemiological evidence of a pathogenetic continuum between borderline and invasive ovarian tumours.
|Titolo:||Risk factors for epithelial ovarian tumours of borderline malignancy|
|Parole Chiave:||Fertility ; Age Factors ; Odds Ratio ; Ovary ; Research Methodology ; Population Dynamics ; Physiology ; Contraceptives, Oral ; Europe ; Italy ; Southern Europe ; Ovulation ; Population Characteristics ; Parental Age ; Ovarian Cancer ; Epithelium ; Diseases ; Neoplasm Invasiveness ; Contraceptive Methods--beneficial effects ; Studies ; Case Control Studies ; Neoplasms ; Abortion, Induced ; Maternal Age ; Urogenital System ; Case-Control Studies ; Population ; Menopause ; Humans ; Fertility Control, Postconception ; Developed Countries ; Genitalia, Female ; Adult ; Demographic Factors ; Family Planning ; Parity ; Ovarian Neoplasms ; Oral Contraceptives--beneficial effects ; Genitalia ; Methodological Studies ; Cancer ; Contraception ; Histology ; Mediterranean Countries ; Nulliparity ; Risk Factors ; Middle Aged ; Fertility Measurements ; Female ; Biology|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
Settore MED/40 - Ginecologia e Ostetricia
|Data di pubblicazione:||dic-1991|
|Digital Object Identifier (DOI):||10.1093/ije/20.4.871|
|Appare nelle tipologie:||01 - Articolo su periodico|