Genotipo 3020insc del gene Nod2/Cardi5 in una casistica di pazienti con malattia di Crohn trattati chirurgicamente

Pseudomixoma peritonei (PMP) is a rare neoplasia with a low grade of clinical malignity. Generally, the main treatment of this tumor is the surgical debulking. Best results are obtained combining surgery and hyperthermic antiblastic peritoneal perfusion (HAPP) with CDDP and MMC. From April '97 to March 2003, we operated on 132 patients, 8 times with a palliative intent. In 27 times we achieved a complete cytoreduction (17 CC0 and 10 CC1) followed by HAPP. As regards results, no post-operative mortality was reported and 19% of major morbidity was observed. 26 patients are NED at maximum follow-up of 6 years and 1 patient had recurrence 6 months after primary resection. We believe that cytoreduction and HAPP is the golden standard of PMP therapy when it is possible to achieve a complete cytoreduction. Most of the times, the disease is not radically treated and therefore, after diagnosis, patients should be only referred to specialized centers.

Specifici genotipi del gene NOD2/CARD 15. e in particolare la mutazione 3020 in sC. sono associati a malattia di Crohn (Crohn), familiare e non. Per il genotipo 3020insC sono riportate variabili prevalenze (da 1.8% a 17 .2 °/t:•) e correlazioni con i comportamenti della malattia , sia fistolizza nt e che stenosante . Le diverse casistiche differiscono per composizione etnica , per prevalenza della malattia familiare. per modalità di reclutamento e trattamento dei pazie nti. Scopi: in pazienti con Crohn sottoposti a trattamento chirurgico , determinare la prevalenza del genotipo 3020insC e quindi valutare se questo correli con specifiche caratteristiche clinico-patologiche.