We studied the activity of plasma membrane (Ca+Mg)ATPase from erythrocytes of Milan hypertensive rat strain (MHS) and Milan low calpastatin rat strain (MLCS), that show an activity level of the specific calpain inhibitor, calpastatin, about five fold reduced in comparison with the Milan normotensive rat strain (MNS), while the protease activity level is similar. This imbalance of calpain:calpastatin ratio leads to a decrease of the erythrocyte plasma membrane (Ca+Mg)ATPase activity and to the appearance of 124 kDa fragments, which are the typical products of proteolytic calpain action on the 136 kDa (Ca+Mg)ATPase native form.

Association between plasma membrane (Ca+Mg)ATP and calpain/calpastatin system in rat erythrocytes / L. Soldati, G. Vezzoli, S. Salardi, R. Spaventa, B.R. Barber, T. Azzani, G. Bianchi. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - 222:2(1996 May 15), pp. 572-575. [10.1006/bbrc.1996.0785]

Association between plasma membrane (Ca+Mg)ATP and calpain/calpastatin system in rat erythrocytes

L. Soldati
Primo
;
G. Vezzoli
Secondo
;
1996

Abstract

We studied the activity of plasma membrane (Ca+Mg)ATPase from erythrocytes of Milan hypertensive rat strain (MHS) and Milan low calpastatin rat strain (MLCS), that show an activity level of the specific calpain inhibitor, calpastatin, about five fold reduced in comparison with the Milan normotensive rat strain (MNS), while the protease activity level is similar. This imbalance of calpain:calpastatin ratio leads to a decrease of the erythrocyte plasma membrane (Ca+Mg)ATPase activity and to the appearance of 124 kDa fragments, which are the typical products of proteolytic calpain action on the 136 kDa (Ca+Mg)ATPase native form.
Settore MED/14 - Nefrologia
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
15-mag-1996
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/205968
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