A recombinant rat strain--Milan low-calpastatin strain (MLCS)--was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a model for studies of the calpain-calpastatin system, which is involved in important cellular mechanisms. Calpastatin polymorphism was observed in 10 different strains of laboratory rats and a single locus hypothesis is suggested as the mode of inheritance.

A new rat model for studying the calpain-calpastatin system / L. Soldati, B.R. Barber, S. Salardi, I. Molinari, G. Bianchi. - In: LABORATORY ANIMALS. - ISSN 0023-6772. - 29:4(1995 Oct), pp. 420-426.

A new rat model for studying the calpain-calpastatin system

L. Soldati
Primo
;
1995

Abstract

A recombinant rat strain--Milan low-calpastatin strain (MLCS)--was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a model for studies of the calpain-calpastatin system, which is involved in important cellular mechanisms. Calpastatin polymorphism was observed in 10 different strains of laboratory rats and a single locus hypothesis is suggested as the mode of inheritance.
Blood pressure; Calpain; Calpastatin; Rat
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
ott-1995
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/205960
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