A recombinant rat strain--Milan low-calpastatin strain (MLCS)--was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a model for studies of the calpain-calpastatin system, which is involved in important cellular mechanisms. Calpastatin polymorphism was observed in 10 different strains of laboratory rats and a single locus hypothesis is suggested as the mode of inheritance.
A new rat model for studying the calpain-calpastatin system / L. Soldati, B.R. Barber, S. Salardi, I. Molinari, G. Bianchi. - In: LABORATORY ANIMALS. - ISSN 0023-6772. - 29:4(1995 Oct), pp. 420-426.
|Titolo:||A new rat model for studying the calpain-calpastatin system|
SOLDATI, LAURA (Primo)
|Parole Chiave:||Blood pressure; Calpain; Calpastatin; Rat|
|Settore Scientifico Disciplinare:||Settore MED/49 - Scienze Tecniche Dietetiche Applicate|
|Data di pubblicazione:||ott-1995|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1258/002367795780740032|
|Appare nelle tipologie:||01 - Articolo su periodico|