Hot flushes are the commonest symptom induced by gonadotropin-releasing hormone agonists (GnRHa). We performed an open observational trial to evaluate the efficacy of veralipride, an antidopaminergic drug, in reducing hot flushes in 25 premenopausal women treated with a GnRHa for endometriosis (8 subjects) or menorrhagia (17 subjects). The patients received goserelin depot for 6 months and veralipride was added for the third month. Hot flushes, severe in all women at 2 months, improved in both frequency and intensity in 92 % of the subjects during veralipride administration. The benefit obtained persisted until the end of the GnRHa treatment.
|Titolo:||Veralipride for hot flushes during gonadotropin-releasing hormone agonist treatment|
|Parole Chiave:||Antidopaminergic drugs; Gonadotropin-releasing hormone agonists; Hot flushes; Veralipride|
|Settore Scientifico Disciplinare:||Settore MED/40 - Ginecologia e Ostetricia|
|Data di pubblicazione:||1992|
|Digital Object Identifier (DOI):||10.1159/000292736|
|Appare nelle tipologie:||01 - Articolo su periodico|