Human probes identifying the cellular homologs of the v-ets gene, Hu-ets-1 and Hu-ets-2, and two panels of rodent-human cell hybrids were used to study specific translocations occurring in acute leukemias. The human ets-1 gene was found to translocate from chromosome 11 to 4 in the t(4;11)(q21;23), a translocation characteristic of a subtype of leukemia that represents the expansion of a myeloid/lymphoid precursor cell. Similarly, the human ets-2 gene was found to translocate from chromosome 21 to chromosome 8 in the t(8;21)(q22;q22), a nonrandom translocation commonly found in patients with acute myeloid leukemia with morphology M2 (AML-M2). Both translocations are associated with expression different from the expression in normal lymphoid cells of ets genes, raising the possibility that these genes play a role in the pathogenesis of these leukemias.
|Titolo:||Hu-ets-1 and Hu-ets-2 genes are transposed in acute leukemias with (4;11) and (8;21) translocations|
SACCHI, NICOLETTA (Primo)
|Parole Chiave:||leukemia ; animals ; oncogenes ; cricetulus ; humans ; hybrid cells ; chromosomes, human, 6-12 and X ; nucleic acid hybridization ; chromosomes, human, 21-22 and Y ; cell line ; translocation, genetic ; cricetinae|
|Settore Scientifico Disciplinare:||Settore BIO/11 - Biologia Molecolare|
|Data di pubblicazione:||24-gen-1986|
|Digital Object Identifier (DOI):||10.1126/science.3941901|
|Appare nelle tipologie:||01 - Articolo su periodico|