The calpain-calpain inhibitor system was evaluated in erythrocytes of patients with essential hypertension and normotensive controls, either with or without a family history of hypertension. Calpain levels were similar in the controls and hypertensive patients, whereas the inhibitor activity level was significantly reduced in the latter (301.8 +/- 26.4 vs 220 +/- 14 U/mg hemoglobin, p less than 0.001). Borderline hypertensive patients and a few controls with a history of hypertension showed low inhibitor activity. Similar results have recently been reported in genetically hypertensive rats of the Milan strain. A significant inverse correlation (r = -0.43, p less than 0.001) was found between mean arterial pressure and calpain inhibitor. Although the pathophysiological significance of these observations is not yet clear, they suggest a new area of investigation into the molecular mechanisms underlying essential hypertension and its complications.

Erythrocyte deficiency in calpain inhibitor activity in essential hypertension / S. Pontremoli, E. Melloni, B. Sparatore, F. Salamino, R. Pontremoli, A. Tizianello, C. Barlassina, D. Cusi, R. Colombo, G. Bianchi. - In: HYPERTENSION. - ISSN 0194-911X. - 12:5(1988 Nov), pp. 474-478.

Erythrocyte deficiency in calpain inhibitor activity in essential hypertension

C. Barlassina;D. Cusi;
1988

Abstract

The calpain-calpain inhibitor system was evaluated in erythrocytes of patients with essential hypertension and normotensive controls, either with or without a family history of hypertension. Calpain levels were similar in the controls and hypertensive patients, whereas the inhibitor activity level was significantly reduced in the latter (301.8 +/- 26.4 vs 220 +/- 14 U/mg hemoglobin, p less than 0.001). Borderline hypertensive patients and a few controls with a history of hypertension showed low inhibitor activity. Similar results have recently been reported in genetically hypertensive rats of the Milan strain. A significant inverse correlation (r = -0.43, p less than 0.001) was found between mean arterial pressure and calpain inhibitor. Although the pathophysiological significance of these observations is not yet clear, they suggest a new area of investigation into the molecular mechanisms underlying essential hypertension and its complications.
Blood Pressure ; Humans ; Erythrocytes ; Adult ; Calpain ; Glycoproteins ; Hypertension
Settore MED/14 - Nefrologia
nov-1988
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/205143
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