The renal abnormality which causes hypertension in the Milan hypertensive strain of rats disappears as hypertension develops. Because of the many analogies between the condition in these rats and "essential" hypertension in man, the same pattern of change may occur if a renal abnormality is the cause of essential hypertension in man. This hypothesis was tested in two groups of young normotensive subjects matched for age, sex, and body-surface area; in the first group both parents were hypertensive, and in the second group both parents were normotensive. Renal plasma-flow, glomerular filtration-rate, plasma-volume, plasma-renin activity, plasma-concentrations of Na+, K+, and catecholamines, 24 h urinary excretion of Na+, K+, and aldosterone, and the cardiac index were measured so that renal function and the role of factors affecting blood-pressure regulation could be assessed. Renal plasma-flow was significantly higher (p less than 0.01) in the first group, whereas results of tests for all the other factors were almost the same in both groups. The hypothesis that a primary kidney abnormality causes hypertension in a proportion of patients with essential hypertension is proposed.
A renal abnormality as a possible cause of essential hypertension / G. Bianchi, D. Cusi, M. Gatti, G.P. Lupi, P. Ferrari, C. Barlassina, G.B. Picotti, G. Bracchi, G. Colombo, D. Gori, O. Velis, D. Mazzei. - In: THE LANCET. - ISSN 0140-6736. - 1:8109(1979 Jan 27), pp. 173-177.
|Titolo:||A renal abnormality as a possible cause of essential hypertension|
CUSI, DANIELE MARIA (Secondo)
|Parole Chiave:||renin ; animals ; kidney function tests ; cardiac output ; blood pressure ; plasma volume ; humans ; potassium ; regional blood flow ; sodium ; rats ; heart rate ; catecholamines ; glomerular filtration rate ; adult ; kidney ; aldosterone ; male ; female ; hypertension|
|Settore Scientifico Disciplinare:||Settore MED/14 - Nefrologia|
Settore MED/03 - Genetica Medica
|Data di pubblicazione:||27-gen-1979|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0140-6736(79)90577-4|
|Appare nelle tipologie:||01 - Articolo su periodico|