Diabetes is a Coronary Artery Disease (CAD) risk equivalent. However, there is a wide variation in prevalence of CAD in diabetes, possibly related to the presence of additional risk factors. Aim : To assess the usefulness of myocardial rest-stress perfusion SPECT (MPS) in diabetic patients with silent or occult CAD in comparison with the existing risk factors.Methodology : Among 402 patients, 105 pts with diabetes mellitus (7 type I; 98 type II) and high likelihood of CAD underwent MPS with 99mTc-Tetrofosmin. Multiple risk factors and clinical predictors were analysed (dyslipidemia, hypertension, smoke, family history of CAD or diabetes, Body Mass Index). Results: According to the SPECT results, patients were classified in: Group A (56 pts with normal MPS), and Group B (12 pts with reversible, 23 pts with mixed, 14 with fixed perfusion defects). Moderate or large stress defects occurred in 10 and 30 pts, respectively. The analysis of the presence of CAD risk factors was not statistically significant (Table 1). Conclusion: MPS detects silent or occult perfusion defects in 47% of patients with diabetes mellitus. The usual risk factor analysis or the association of 2 or more of these, are inadequate to predict the presence of CAD in this population. Surprisingly in this population a relevant incidence (35%) of silent myocardial infarction was detected.

Potential role of myocardial perfusion SPECT in detection of occult CAD: a prospective observational multicentre study in diabetic patients (Mille-Miglia Registry Group) / L. Florimonte, L. Maffioli, R. Giubbini, U. Guerra, A. Bruno, A. Bestetti, F. Bertagna, C. DI L. E. O.. - In: JOURNAL OF NUCLEAR CARDIOLOGY. - ISSN 1071-3581. - 14:2(2007 Mar), pp. S44-S44. ((Intervento presentato al 8. convegno INTERNATIONAL CONFERENCE OF NUCLEAR CARDIOLOGY tenutosi a PRAGUE nel 2007.

Potential role of myocardial perfusion SPECT in detection of occult CAD: a prospective observational multicentre study in diabetic patients (Mille-Miglia Registry Group)

A. Bestetti;
2007

Abstract

Diabetes is a Coronary Artery Disease (CAD) risk equivalent. However, there is a wide variation in prevalence of CAD in diabetes, possibly related to the presence of additional risk factors. Aim : To assess the usefulness of myocardial rest-stress perfusion SPECT (MPS) in diabetic patients with silent or occult CAD in comparison with the existing risk factors.Methodology : Among 402 patients, 105 pts with diabetes mellitus (7 type I; 98 type II) and high likelihood of CAD underwent MPS with 99mTc-Tetrofosmin. Multiple risk factors and clinical predictors were analysed (dyslipidemia, hypertension, smoke, family history of CAD or diabetes, Body Mass Index). Results: According to the SPECT results, patients were classified in: Group A (56 pts with normal MPS), and Group B (12 pts with reversible, 23 pts with mixed, 14 with fixed perfusion defects). Moderate or large stress defects occurred in 10 and 30 pts, respectively. The analysis of the presence of CAD risk factors was not statistically significant (Table 1). Conclusion: MPS detects silent or occult perfusion defects in 47% of patients with diabetes mellitus. The usual risk factor analysis or the association of 2 or more of these, are inadequate to predict the presence of CAD in this population. Surprisingly in this population a relevant incidence (35%) of silent myocardial infarction was detected.
Settore MED/36 - Diagnostica per Immagini e Radioterapia
mar-2007
AMERICAN SOCIETY OF NUCLEAR CARDIOLOGY
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/204423
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