We evaluated the frequency of serum antineuronal antibodies in a cohort of 39 neuroblastoma patients and related their presence to clinical features. Twelve patients displayed antineuronal antibodies at immunocytochemistry. Only one of these 12 patients suffered from a clinically overt paraneoplastic syndrome. No significant differences emerged between autoantibody-positive and autoantibody-negative patients in terms of progression-free and overall survival, although when only patients evolving to disease progression were considered, the time interval between diagnosis and progression was slightly longer in autoantibody-positive patients.
|Titolo:||Antineuronal antibodies in patients with neuroblastoma : relationships with clinical features|
NEMNI, RAFFAELLO (Ultimo)
|Parole Chiave:||Humans ; Disease Progression ; Child ; Neuroblastoma ; Child, Preschool ; Infant ; Blotting, Western ; Paraneoplastic Syndromes; Autoantibodies ; Neurons ; Cohort Studies ; Adolescent ; Immunohistochemistry ; Female ; Male ; Survival Analysis|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
Settore MED/06 - Oncologia Medica
|Data di pubblicazione:||1997|
|Appare nelle tipologie:||01 - Articolo su periodico|