We evaluated the frequency of serum antineuronal antibodies in a cohort of 39 neuroblastoma patients and related their presence to clinical features. Twelve patients displayed antineuronal antibodies at immunocytochemistry. Only one of these 12 patients suffered from a clinically overt paraneoplastic syndrome. No significant differences emerged between autoantibody-positive and autoantibody-negative patients in terms of progression-free and overall survival, although when only patients evolving to disease progression were considered, the time interval between diagnosis and progression was slightly longer in autoantibody-positive patients.
Antineuronal antibodies in patients with neuroblastoma : relationships with clinical features / A. Salmaggi, R. Luksch, M.G. Forno, A. Pozzi, A. Silvani, A. Boiardi, M. Gasparini, R. Nemni. - In: TUMORI. - ISSN 0300-8916. - 83:6(1997), pp. 953-957.
Antineuronal antibodies in patients with neuroblastoma : relationships with clinical features
R. NemniUltimo
1997
Abstract
We evaluated the frequency of serum antineuronal antibodies in a cohort of 39 neuroblastoma patients and related their presence to clinical features. Twelve patients displayed antineuronal antibodies at immunocytochemistry. Only one of these 12 patients suffered from a clinically overt paraneoplastic syndrome. No significant differences emerged between autoantibody-positive and autoantibody-negative patients in terms of progression-free and overall survival, although when only patients evolving to disease progression were considered, the time interval between diagnosis and progression was slightly longer in autoantibody-positive patients.Pubblicazioni consigliate
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