Surgical reconstruction of the anterior cruciate ligament (ACL) does not necessarily decrease the risk of developing osteoarthritis (OA). The inflammatory response and relative changes in pro- and anti-inflammatory cytokines could participate in triggering the development of OA. To test this hypothesis we measured the concentrations of IL-1β, IL-1ra, IL-6, IL-8, IL-10, and TNF-α at different times after ACL rupture. The sample population consisted of 48 patients with ACL tear which were assigned to different groups according to the time elapsed from the injury: 22 acute (A), 7 early sub-acute (ESA), 11 late sub-acute (LSA), and 8 chronic (C). In group A, there were high levels of IL-1β, IL-6, and IL-8, whereas levels of IL-1ra and TNF-α were significantly lower than usually reported. IL-1β and IL-8 concentrations returned with time to normal levels in the ESA group. Interestingly, IL-1ra levels remained always significantly lower than normally reported levels, and TNF-α levels did not increase after trauma. Our data show increased level of pro-inflammatory cytokines (IL-6 and IL-8) in the acute phase of inflammation which could be responsible for triggering cartilage catabolism and suggest that prompt neutralization of IL-6 and IL-8 accumulations in synovial fluid could help prevent development of OA in ACL-injured knees.
Acute and late changes in intraarticular cytokine levels following anterior cruciate ligament injury / M. Bigoni, P. Sacerdote, M. Turati, S. Franchi, M. Gandolla, D. Gaddi, S. Moretti, D. Munegato, C.A. Augusti, E. Bresciani, R.J. Omeljaniuk, V. Locatelli, A. Torsello. - In: JOURNAL OF ORTHOPAEDIC RESEARCH. - ISSN 0736-0266. - 31:2(2013 Feb), pp. 315-321.
|Titolo:||Acute and late changes in intraarticular cytokine levels following anterior cruciate ligament injury|
SACERDOTE, PAOLA GIUSEPPINA (Secondo)
|Parole Chiave:||ACL tear; cytokines; knee; osteoarthritis; synovial|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
Settore MED/33 - Malattie Apparato Locomotore
|Data di pubblicazione:||feb-2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jor.22208|
|Appare nelle tipologie:||01 - Articolo su periodico|
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