Two females mother and daughter, were affected by a neuromuscular disorder, characterized by slow progression, humeroperoneal weakness and wasting, limited neck flexion, elbow and ankle joint contractures, cardiopathy and myopathic pattern on EMG. Muscle histology and histochemistry showed type I fiber atrophy and predominance in both. Cardiac abnormalities, in the first case, were suggestive of a hypertrophic cardiomyopathy while in the second hypotension and chronic bradycardia were present. Neurological signs, EMG and morphology seemed to point to a genetic variant of the form of dystrophy named Emery-Dreifuss disease. The mode of transmission and cardiac abnormalities, however, raise the problem of variability even in this well-defined, usually X-linked, disorder.
|Titolo:||Autosomal-dominant dystrophy with humeroperoneal weakness and cardiopathy : a genetic variant of Emery-Dreifuss disease?|
|Parole Chiave:||Emery-Dreifuss disease; fiber atrophy and predominance; X-linked inheritance|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||feb-1986|
|Digital Object Identifier (DOI):||10.1007/BF02230430|
|Appare nelle tipologie:||01 - Articolo su periodico|