In order to investigate the role of paraproteins in the production of neuropathy we experimentally induced monoclonal immunoglobulin-producing tumours into 32 BALB/c mice by injecting mineral oil or pristane intraperitoneally. In 11 mice morphologic and histometric studies of the sciatic nerve revealed the presence of neuropathy. Immunohistochemical studies did not demonstrate a significant amount of immunoglobulins and light chains in the endoneurium. The advantages and limits of this experimental model are discussed.
Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse / R. Nemni, R. Fazio, M. Corbo, C. Sacchi, S. Smirne, N. Canal. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - 77:2-3(1987 Feb), pp. 321-329.
Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse
R. NemniPrimo
;R. FazioSecondo
;S. SmirnePenultimo
;N. CanalUltimo
1987
Abstract
In order to investigate the role of paraproteins in the production of neuropathy we experimentally induced monoclonal immunoglobulin-producing tumours into 32 BALB/c mice by injecting mineral oil or pristane intraperitoneally. In 11 mice morphologic and histometric studies of the sciatic nerve revealed the presence of neuropathy. Immunohistochemical studies did not demonstrate a significant amount of immunoglobulins and light chains in the endoneurium. The advantages and limits of this experimental model are discussed.
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