We report a patient with a progressive, predominantly sensory neuropathy and a IgM kappa M-protein that binds to Schmidt-Lantermann incisures. A sural nerve biopsy showed primary axonal damage and IgM deposits at Schmidt-Lantermann incisures were seen by direct immunoperoxidase. Serum from the patient injected into rat sciatic nerve reacts with the incisures as with those in the patient's nerve. The IgM kappa M-protein reacts with chondroitin sulfate C and binds to a broad nerve protein band with a mobility of between 170 and 118 kDa. Peripheral neuropathy may be related to the M-protein, which had immunocytochemical reactivity not previously described for patients with polyneuropathy and IgM monoclonal gammopathy.
Axonal neuropathy in a patient with monoclonal IgM kappa reactive with Schmidt-Lantermann incisures / A. Quattrini, R. Nemni, R. Fazio, S. Iannaccone, I. Lorenzetti, F. Grassi, N. Canal. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 33:1(1991 Jul), pp. 73-79.
Axonal neuropathy in a patient with monoclonal IgM kappa reactive with Schmidt-Lantermann incisures
R. Nemni;R. Fazio;N. Canal
1991
Abstract
We report a patient with a progressive, predominantly sensory neuropathy and a IgM kappa M-protein that binds to Schmidt-Lantermann incisures. A sural nerve biopsy showed primary axonal damage and IgM deposits at Schmidt-Lantermann incisures were seen by direct immunoperoxidase. Serum from the patient injected into rat sciatic nerve reacts with the incisures as with those in the patient's nerve. The IgM kappa M-protein reacts with chondroitin sulfate C and binds to a broad nerve protein band with a mobility of between 170 and 118 kDa. Peripheral neuropathy may be related to the M-protein, which had immunocytochemical reactivity not previously described for patients with polyneuropathy and IgM monoclonal gammopathy.Pubblicazioni consigliate
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