We report a patient with a progressive, predominantly sensory neuropathy and a IgM kappa M-protein that binds to Schmidt-Lantermann incisures. A sural nerve biopsy showed primary axonal damage and IgM deposits at Schmidt-Lantermann incisures were seen by direct immunoperoxidase. Serum from the patient injected into rat sciatic nerve reacts with the incisures as with those in the patient's nerve. The IgM kappa M-protein reacts with chondroitin sulfate C and binds to a broad nerve protein band with a mobility of between 170 and 118 kDa. Peripheral neuropathy may be related to the M-protein, which had immunocytochemical reactivity not previously described for patients with polyneuropathy and IgM monoclonal gammopathy.
|Titolo:||Axonal neuropathy in a patient with monoclonal IgM kappa reactive with Schmidt-Lantermann incisures|
|Parole Chiave:||Autoimmunity; Chondroitin sulfate C; Monoclonal gammopathy; Neuropathy; Schmidt-Lantermann incisure|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
Settore MED/04 - Patologia Generale
|Data di pubblicazione:||lug-1991|
|Digital Object Identifier (DOI):||10.1016/0165-5728(91)90036-7|
|Appare nelle tipologie:||01 - Articolo su periodico|