We treated adult mice with human recombinant interleukin-2 (IL-2) and determined the expression of the genes encoding for the major central and peripheral myelin proteins. In the CNS, myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) mRNA levels were the same both in IL-2-treated and in control mice. Proteolipid protein (PLP) transcript was decreased in IL-2-treated animals when compared to controls. In the PNS, the messages for the glycoprotein P0 and for MBP were markedly increased in IL-2-treated animals when compared to controls.
In vivo modulation of myelin gene expression by human recombinant IL-2 / M. Sessa, R. Nemni, S. Iannaccone, A. Quattrini, V. Confalonieri, N. Canal. - In: MOLECULAR BRAIN RESEARCH. - ISSN 0169-328X. - 12:4(1992 Feb), pp. 331-334.
In vivo modulation of myelin gene expression by human recombinant IL-2
R. NemniSecondo
;N. CanalUltimo
1992
Abstract
We treated adult mice with human recombinant interleukin-2 (IL-2) and determined the expression of the genes encoding for the major central and peripheral myelin proteins. In the CNS, myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) mRNA levels were the same both in IL-2-treated and in control mice. Proteolipid protein (PLP) transcript was decreased in IL-2-treated animals when compared to controls. In the PNS, the messages for the glycoprotein P0 and for MBP were markedly increased in IL-2-treated animals when compared to controls.
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