Acipimox (5-methylpyrazine carboxylic acid 4-oxide) is a new inhibitor of lipolysis with long-lasting activity, whose plasma lipid lowering potential was demonstrated in early clinical trials. The hypolipidemic effect of acipimox was investigated in two double-blind cross-over trials versus placebo. The first trial, carried out in 12 type IV patients, showed a significant triglyceride lowering effect (-35%) following 4 weeks of drug administration at a 250 tid dose. The same regimen, maintained for 9 weeks in 18 type IIa patients, failed to induce a significant reduction of total cholesterolemia. However, in 10 subjects, in whom lipoprotein cholesterol fractionation was carried out, a significant reduction of low density and a highly significant increase in high density lipoprotein cholesterol levels (respectively -11% and +20%) were observed.
|Titolo:||Reduced triglyceridemia and increased high density lipoprotein cholesterol levels after treatment with acipimox, a new inhibitor of lipolysis|
SIRTORI, CESARE (Primo)
|Parole Chiave:||Acipimox; High density lipoproteins; Hyperlipoproteinemias; Lipolysis inhibitors|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1981|
|Digital Object Identifier (DOI):||10.1016/0021-9150(81)90042-3|
|Appare nelle tipologie:||01 - Articolo su periodico|