Primary biliary cirrhosis (PBC) is an autoimmune disease of unknown etiology leading to progressive destruction of intrahepatic bile duct, with cholestasis, cirrhosis, and eventually liver failure. Epidemiological data indicate that environmental factors trigger autoimmunity in genetically susceptible individuals, although no definitive association of PBC with specific genes has been found. Further, no convincing explanation has been provided for the strong female predominance observed in the prevalence of PBC. However, we recently suggested that the enhanced monosomy X in peripheral white blood cells, and particularly in lymphocytes, of affected women might play a role in the induction of PBC. Such observations appear independent from the degree of cholestasis and specific for PBC. In this review we discuss the implications of these findings and their immunological implications.
|Titolo:||Primary biliary cirrhosis : does X mark the spot?|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
Settore MED/03 - Genetica Medica
|Data di pubblicazione:||2004|
|Digital Object Identifier (DOI):||10.1016/j.autrev.2004.05.003|
|Appare nelle tipologie:||01 - Articolo su periodico|