A 65-year-old man with IgG lambda multiple myeloma developed severe polyneuropathy with prominent thermal-pain sensory impairment and autonomic failure. Although the clinical presentation suggested amyloid neuropathy, nerve biopsy showed the immunohistochemical and ultrastructural features typical of light chain deposition disease (LCDD). A precise morphologic and clinical description of LCDD neuropathy is given for the first time in the present report.
Light chain deposition disease neuropathy resembling amyloid neuropathy in a multiple myeloma patient / M. P. Grassi, F. Clerici, C. Perin, M. Borella, A. Gendarini, A. Quattrini, R. Nemni, A. Mangoni. - In: ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES. - ISSN 0392-0461. - 19:4(1998 Aug), pp. 229-233. [10.1007/BF02427609]
Light chain deposition disease neuropathy resembling amyloid neuropathy in a multiple myeloma patient
R. Nemni;
1998
Abstract
A 65-year-old man with IgG lambda multiple myeloma developed severe polyneuropathy with prominent thermal-pain sensory impairment and autonomic failure. Although the clinical presentation suggested amyloid neuropathy, nerve biopsy showed the immunohistochemical and ultrastructural features typical of light chain deposition disease (LCDD). A precise morphologic and clinical description of LCDD neuropathy is given for the first time in the present report.
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