Investigations on new agents for hyperlipidemia should consider the proper choice of an animal model, and the possible mechanisms of action of the agent. Animal models may include dietary and drug induced hyperlipidemias, as well as genetic or spontaneous forms of atherosclerosis. The activity of various drugs on the models may provide indications on their mechanism of action. Lipoprotein metabolism is somewhat different in the various animal species, an about constant feature being the appearance of abnormal lipoproteins following dietary cholesterol. In some cases these lipoproteins do not markedly differ from those of some types of human disease. Structure-activity relationship of hypolipidemic drugs is not clear due to the variety of compounds tested up to now. In general, clofibrate and its derivatives exert numerous effects both on lipid absorption and transport. Surgical procedures, such as partial ileal bypass, and portocaval shunt, hold promise for cases which respond poorly to diet and drug treatments.
|Titolo:||Drugs, lipids and atherosclerosis|
SIRTORI, CESARE (Primo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1975|
|Digital Object Identifier (DOI):||10.1016/S0031-6989(75)80014-2|
|Appare nelle tipologie:||01 - Articolo su periodico|