Recent data suggest that abnormalities of T CD4+CD25+ T cells (T-reg) contribute to the pathogenesis of autoimmunity in primary biliary cirrhosis (PBC). Serum levels of soluble IL2 receptor alpha (sIL2ra) are indicators of peripheral T-reg. Several studies have demonstrated increased sIL2ra levels during chronic viral hepatitis or autoimmune diseases. Aim of the present study was to determine if changes in serum sIL2ra levels characterized women with PBC at different stages.
Serum levels of soluble interleukin 2 receptor a in patients with primary biliary cirrhosis / M. Bignotto, V. Pozzoli, P. Zermiani, F. Bernuzzi, P. Invernizzi, M. Podda, M. Zuin, C. Selmi. ((Intervento presentato al 6. convegno International Congress on Autoimmunity tenutosi a Porto nel 2008.
Serum levels of soluble interleukin 2 receptor a in patients with primary biliary cirrhosis
M. Bignotto;P. Zermiani;M. Podda;M. Zuin;C. Selmi
2008-09-03
Abstract
Recent data suggest that abnormalities of T CD4+CD25+ T cells (T-reg) contribute to the pathogenesis of autoimmunity in primary biliary cirrhosis (PBC). Serum levels of soluble IL2 receptor alpha (sIL2ra) are indicators of peripheral T-reg. Several studies have demonstrated increased sIL2ra levels during chronic viral hepatitis or autoimmune diseases. Aim of the present study was to determine if changes in serum sIL2ra levels characterized women with PBC at different stages.
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