GC/ms is an important method to determine drugs in biological fluids. For each of the most commonly used drugs a methanolic solution (100 μg/ml) was prepared; 30 μl of each solution was evaporated using nitrogen flow and than diluted in 100 ml of a derivatizing mixture constituted by MSTFA and toluene (30/70). After a short reaction time at room temperature 1 ml of each solution was injected into a SE-52 column (15 m x 0.25 mm) using chemical ionization with acetonitrile. This method has a good signal/noise ratio and is very useful in screening techniques.
Determination of substances of abuse in biological fluids by GC/MS using chemical ionization with acetonitrile / C. Mariani, G. Crespi, M. Montana, E. Pini, R. Stradi. - In: BOLLETTINO CHIMICO FARMACEUTICO. - ISSN 0006-6648. - 138:8(1999), pp. 440-445.
Determination of substances of abuse in biological fluids by GC/MS using chemical ionization with acetonitrile
E. Pini;R. Stradi
1999
Abstract
GC/ms is an important method to determine drugs in biological fluids. For each of the most commonly used drugs a methanolic solution (100 μg/ml) was prepared; 30 μl of each solution was evaporated using nitrogen flow and than diluted in 100 ml of a derivatizing mixture constituted by MSTFA and toluene (30/70). After a short reaction time at room temperature 1 ml of each solution was injected into a SE-52 column (15 m x 0.25 mm) using chemical ionization with acetonitrile. This method has a good signal/noise ratio and is very useful in screening techniques.
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