Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive β-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of β-endorphin in mononuclear leukocytes of 30.2 ± 6.9 pg/ 10 6 cells on admission were in the normal range of 20-40 pg/10 6 cells and decreased significantly to 6.9 ± 1.9 pg/10 6 cells after 48 h (p < 0.05). Decreased levels of mononuclear leukocyte-associated β-endorphin in acute myocardial infarction may be due to the release of endogenous opioid after stimulation by stress and acute-phase reactants and play a role in inflammation and pain.
Decreased levels of B-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction / T. BURATTI, P. SHRATZENBERGER, S. DUNZENDORFER, S.E. MANFREDA, C. PECHLANER, M. JOANNIDIS, P. SACERDOTE, A.E. PANERAI, C.J. WIEDERMANN. - In: CARDIOLOGY. - ISSN 0008-6312. - 90:1(1998), pp. 43-47.
|Titolo:||Decreased levels of B-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction|
PANERAI, ALBERTO EMILIO (Penultimo)
|Parole Chiave:||Acute myocardial infarction; C-reactive protein; Immunoreactive β-endorphin; Leukocytes|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1998|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000006815|
|Appare nelle tipologie:||01 - Articolo su periodico|