β-Endorphin (β-EP) and cholecystokinin 8 (CCK-8) concentrations in peripheral blood mononuclear cells were measured in 12 drug-free autistic (AU) children, in 10 drug-free children with pervasive developmental disorders (PDD) and in 11 healthy controls. The aim of the study was to see whether or not there was an alteration of β-EP and CCK-8 concentrations in this peripheral compartment, in which it has been suggested that secretion and regulation of the two peptides mimic those of neurons in the central nervous system. Mean β-EP values were significantly higher in AU than in PDD and control children, while there were no differences in CCK-8 values of the three groups.
Beta-endorphin and cholecystokinin-8 concentrations in peripheral blood mononuclear cells of autistic children / F. BRAMBILLA, A. GUARESCHI CAZZULLO, C. TACCHINI, C. MUSETTI, A.E. PANERAI, P. SACERDOTE. - In: NEUROPSYCHOBIOLOGY. - ISSN 0302-282X. - 35:1(1997), pp. 1-4.
|Titolo:||Beta-endorphin and cholecystokinin-8 concentrations in peripheral blood mononuclear cells of autistic children|
PANERAI, ALBERTO EMILIO (Penultimo)
SACERDOTE, PAOLA GIUSEPPINA (Ultimo)
|Parole Chiave:||β-endorphin; Autism; Cholecystokinin 8; Peripheral blood mononuclear cells; Pervasive developmental disorders|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
Settore MED/25 - Psichiatria
|Data di pubblicazione:||1997|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000119322|
|Appare nelle tipologie:||01 - Articolo su periodico|