IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.

AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.

In biology and medicine we may observe a wide spectrum of formation of patterns, usually due to self-organization phenomena. This may happen at any scale; from the cellular scale of embryonic tissue formation, wound healing or tumor growth, and angiogenesis to the much larger scale of animal grouping. Patterns are usually explained in terms of a collective behavior driven by “forces,” either external and/or internal, acting upon individuals (cells or organisms). In most of these organization phenomena, randomness plays a major role; here we wish to address the issue of the relevance of randomness as a key feature for producing nontrivial geometric patterns in biological structures. As working examples we offer a review of two important case studies involving angiogenesis, i.e., tumor-driven angiogenesis and retina angiogenesis. In both cases the reactants responsible for pattern formation are the cells organizing as a capillary network of vessels, and a family of underlying fields driving the organization, such as nutrients, growth factors, and alike.

A multiscale approach leading to hybrid mathematical models for angiogenesis: the role of randomness / V. Capasso, D. Morale - In: Mathematical methods and models in biomedicine / [a cura di] U. Ledzewicz, H. Schättler, A. Friedman, E. Kashdan. - [s.l] : Springer, 2013. - ISBN 978-1-4614-4177-9. - pp. 87-115

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