T-cell activation is dependent on signals delivered through the antigen-specific T-cell receptor and accessory receptors on T-cells. Integration of signals through this family of costimulatory and inhibitory receptors and their ligands regulates the balance between T-cell activation, tolerance, and immunopathology. Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals and exert a vital and diverse range of immunoregulatory roles in T-cell activation, tolerance, and immune-mediated tissue damage. In this review, we revisit current understanding of the immunoregulatory functions of PD-1 and its ligands and their involvement in immune-mediated diseases.
The PD-1/PD-L1 pathway in human pathology / M. Saresella, V. Rainone, N.M. Al-Daghri, M.S. Clerici, D.L. Trabattoni. - In: CURRENT MOLECULAR MEDICINE. - ISSN 1566-5240. - 12:3(2012 Mar), pp. 259-267.
|Titolo:||The PD-1/PD-L1 pathway in human pathology|
RAINONE, VERONICA (Secondo)
CLERICI, MARIO SALVATORE (Penultimo)
TRABATTONI, DARIA LUCIA (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||mar-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.2174/156652412799218903|
|Appare nelle tipologie:||01 - Articolo su periodico|