Exercise oscillatory breathing (EOB) is a ventilatory abnormality that occurs in ∼20% of heart failure (HF) patients and carries a very unfavourable prognosis. Pulmonary vasoconstriction has been suggested to be involved in this disorder. We hypothesized that modulation of pulmonary vascular hypertone by oversignalling of the nitric oxide pathway with phosphodiesterase 5 (PDE5) inhibition might be beneficial. Accordingly, we performed a 1-year pilot trial with sildenafil in patients with HF and EOB.
|Titolo:||Phosphodiesterase 5 inhibition with sildenafil reverses exercise oscillatory breathing in chronic heart failure : a long-term cardiopulmonary exercise testing placebo-controlled study|
GUAZZI, MARCO (Primo)
|Parole Chiave:||Exercise oscillatory breathing; PDE5 inhibition; Pulmonary pressure|
|Settore Scientifico Disciplinare:||Settore MED/11 - Malattie dell'Apparato Cardiovascolare|
|Data di pubblicazione:||gen-2012|
|Digital Object Identifier (DOI):||10.1093/eurjhf/hfr147|
|Appare nelle tipologie:||01 - Articolo su periodico|