Exercise oscillatory breathing (EOB) is a ventilatory abnormality that occurs in ∼20% of heart failure (HF) patients and carries a very unfavourable prognosis. Pulmonary vasoconstriction has been suggested to be involved in this disorder. We hypothesized that modulation of pulmonary vascular hypertone by oversignalling of the nitric oxide pathway with phosphodiesterase 5 (PDE5) inhibition might be beneficial. Accordingly, we performed a 1-year pilot trial with sildenafil in patients with HF and EOB.

Phosphodiesterase 5 inhibition with sildenafil reverses exercise oscillatory breathing in chronic heart failure : a long-term cardiopulmonary exercise testing placebo-controlled study / M. Guazzi, M. Vicenzi, R. Arena. - In: EUROPEAN JOURNAL OF HEART FAILURE. - ISSN 1388-9842. - 14:1(2012 Jan), pp. 82-90.

Phosphodiesterase 5 inhibition with sildenafil reverses exercise oscillatory breathing in chronic heart failure : a long-term cardiopulmonary exercise testing placebo-controlled study

M. Guazzi;M. Vicenzi;
2012-01

Abstract

Exercise oscillatory breathing (EOB) is a ventilatory abnormality that occurs in ∼20% of heart failure (HF) patients and carries a very unfavourable prognosis. Pulmonary vasoconstriction has been suggested to be involved in this disorder. We hypothesized that modulation of pulmonary vascular hypertone by oversignalling of the nitric oxide pathway with phosphodiesterase 5 (PDE5) inhibition might be beneficial. Accordingly, we performed a 1-year pilot trial with sildenafil in patients with HF and EOB.
Exercise oscillatory breathing; PDE5 inhibition; Pulmonary pressure
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
EUROPEAN JOURNAL OF HEART FAILURE
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/202411
Citazioni
  • ???jsp.display-item.citation.pmc??? 28
  • Scopus 84
  • ???jsp.display-item.citation.isi??? 82
social impact