Preparation of high specific activity radiotracers for radioanalytical studies

This work reviews the more recent advances in this field carried out by the authors groups. High specific activity radiotracers are very suitable for studies related to the toxicol. impact of trace elements onto human health. In order to investigate the metabolic behavior of Low Level Exposure (LLE) to trace elements, it is necessary to carry out in-vitro and in-vivo expts. with tracers whose concn. is of the same order of magnitude as the present environmental exposure values (ng-μg/kg day). Prepns., sepns. and purifications of some no carrier added (NCA) radiotracers (48V, 95m,96Tc, 195m,g,197m,gHg, 199Au, 202Tl) produced by either cyclotron or nuclear reactor irradn., are presented and discussed. 23 Refs.