The production of aliphatic and aromatic aldehydes by oxidation of primary alcohols was achieved with Gluconobacter oxydans DSM 2343. The biotransformation was optimised studying the oxidation of 2-phenyl-1-ethanol to 2-phenylacetaldehyde. A high molar conversion (95% chromatographic conversion, 83% of isolated yield) was obtained using cells grown on glycerol as the main carbon source and directly used in the cultural medium after 24 h at 28°C, pH 4.5 and 5 g L−1 substrate concentration. The conversion of structurally different primary alcohols was performed under these conditions allowing the chemoselective production of aldehydes, sometimes with very good yields.
Chemoselective oxidation of primary alcohols to aldehydes with Gluconobacter oxydans / R. Villa, A. Romano, R. Gandolfi, J.V. Sinisterra Gago, F. Molinari. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 43:34(2002), pp. 6059-6061.
|Titolo:||Chemoselective oxidation of primary alcohols to aldehydes with Gluconobacter oxydans|
ROMANO, ANDREA (Secondo)
MOLINARI, FRANCESCO ENZO (Ultimo)
|Parole Chiave:||Alcohol oxidation; Aldehyde production; Biotransformation; Flavour; Gluconobacter oxydans|
|Settore Scientifico Disciplinare:||Settore CHIM/11 - Chimica e Biotecnologia delle Fermentazioni|
|Data di pubblicazione:||2002|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0040-4039(02)01221-2|
|Appare nelle tipologie:||01 - Articolo su periodico|