Despite the cyclotron production method and the efficiency of the radiochemical procedures adopted, the long-lived radio-isotopic impurity 202Tl is always present in [201Tl]-labelled radio-pharmaceuticals, together with other short-lived impurities like, 200Tl. Rapid determination of the 202Tl impurity, can be achieved using HPGe gamma spectrometry and a detector shielded by a 5 mm thick envelope of lead. In this way, dead-time correction errors, Compton and X-ray background, are very efficiently avoided and suppressed. The same method could be applied routinely in nuclear medicine, to determine the radioisotopic purity of 201Tl by means of an ionisation chamber dose calibrator.

A rapid improved method for gamma- spectrometric determination of 202Tl impurities, in [201Tl]-labelled radiopharmaceuticals / M. Bonardi, F. Groppi, C. Birattari. - In: APPLIED RADIATION AND ISOTOPES. - ISSN 0969-8043. - 57:5(2002), pp. 647-655.

A rapid improved method for gamma- spectrometric determination of 202Tl impurities, in [201Tl]-labelled radiopharmaceuticals

M. Bonardi
Primo
;
F. Groppi
Secondo
;
C. Birattari
Ultimo
2002

Abstract

Despite the cyclotron production method and the efficiency of the radiochemical procedures adopted, the long-lived radio-isotopic impurity 202Tl is always present in [201Tl]-labelled radio-pharmaceuticals, together with other short-lived impurities like, 200Tl. Rapid determination of the 202Tl impurity, can be achieved using HPGe gamma spectrometry and a detector shielded by a 5 mm thick envelope of lead. In this way, dead-time correction errors, Compton and X-ray background, are very efficiently avoided and suppressed. The same method could be applied routinely in nuclear medicine, to determine the radioisotopic purity of 201Tl by means of an ionisation chamber dose calibrator.
γ-spectrometry; 201Tl; 202Tl impurity; Absorption; Dead time; Sample shielding
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore CHIM/03 - Chimica Generale e Inorganica
2002
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/201595
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 6
social impact