The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any intracellular receptor, utilising a reporter gene inducible by natural or synthetic molecules which modulate the activity of such receptor. The mammal is question is preferably a mouse.
A transgenic mouse for screening and pharmacodynamic and pharmacokynetic studies of ligands of estrogen and intracellular receptors and method for its preparation / A.C. Maggi, P. Ciana.
A transgenic mouse for screening and pharmacodynamic and pharmacokynetic studies of ligands of estrogen and intracellular receptors and method for its preparation
A.C. MaggiPrimo
;P. CianaUltimo
2002
Abstract
The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any intracellular receptor, utilising a reporter gene inducible by natural or synthetic molecules which modulate the activity of such receptor. The mammal is question is preferably a mouse.File in questo prodotto:
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