The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any intracellular receptor, utilising a reporter gene inducible by natural or synthetic molecules which modulate the activity of such receptor. The mammal is question is preferably a mouse.

A transgenic mouse for screening and pharmacodynamic and pharmacokynetic studies of ligands of estrogen and intracellular receptors and method for its preparation / A.C. Maggi, P. Ciana.

A transgenic mouse for screening and pharmacodynamic and pharmacokynetic studies of ligands of estrogen and intracellular receptors and method for its preparation

A.C. Maggi
Primo
;
P. Ciana
Ultimo
2002-01-10

Abstract

The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any intracellular receptor, utilising a reporter gene inducible by natural or synthetic molecules which modulate the activity of such receptor. The mammal is question is preferably a mouse.
Università degli Studi di Milano
WO2002/001949
PCT/EP01/07622
Settore BIO/14 - Farmacologia
Settore BIO/18 - Genetica
http://v3.espacenet.com/publicationDetails/biblio?CC=WO&NR=0201949A3&KC=A3&FT=D&date=20020418&DB=EPODOC&locale=en_EP
A transgenic mouse for screening and pharmacodynamic and pharmacokynetic studies of ligands of estrogen and intracellular receptors and method for its preparation / A.C. Maggi, P. Ciana.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/20151
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