Previous studies on genetic rat hypertension have shown that polymorphism within the alpha-adducin gene may regulate blood pressure. Adducin is a cytoskeletal protein that may be involved in cellular signal transduction and interacts with other membrane-skeleton proteins that affect ion transport across the cell membrane. There is a high homology between rat and human adducin and pathophysiological similarities between the Milan hypertensive rat strain and a subgroup of patients with essential hypertension. Thus, we designed a case-control study to test the possible association between the alpha-adducin locus and hypertension. One hundred ninety primary hypertensive patients were compared with 126 control subjects. All subjects were white and unrelated. Four multiallelic markers surrounding the cr-adducin locus located in 4p16.3 were selected: D4S125 and D4S95 mapping at 680 and 20 kb centromeric, and D4S43 and D4S228/E24 mapping at 660 and 2500 kb telomeric. Alleles for each marker were pooled into groups. Comparisons between control subjects and hypertensive patients were carried out by testing the allele-disease association relative to the marker genotype. The maximal association occurred for D4S95 (chi(1)(2) 13.33), which maps closest to alpha-adducin. These data suggest that a polymorphism within the alpha-adducin gene may affect blood pressure in humans.
|Titolo:||ASSOCIATION OF THE ALPHA-ADDUCIN LOCUS WITH ESSENTIAL-HYPERTENSION|
BARLASSINA, MARIA CRISTINA (Secondo)
|Parole Chiave:||case-control studies; cytoskeleton; genes; hypertension, essential; polymorphism (genetics)|
|Settore Scientifico Disciplinare:||Settore MED/03 - Genetica Medica|
Settore MED/14 - Nefrologia
|Data di pubblicazione:||1995|
|Appare nelle tipologie:||01 - Articolo su periodico|