An association between schizophrenia and the T102C polymorphism of the gene for 5-hydroxytryptamine type 2a (5-HT2a) receptor has been reported; the proportion of allele 2 of this polymorphism is higher than expected among schizophrenic patients. We looked for an association between schizophrenia and this variant of the 5-HT2a-receptor gene in a large multicentre study.

Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group / J. Williams, G. Spurlock, P. McGuffin, J. Mallet, M. M. Nöthen, M. Gill, H. Aschauer, P. O. Nylander, F. Macciardi, M. J. Owen. - In: THE LANCET. - ISSN 0140-6736. - 347:9011(1996 May 11), pp. 1294-6-1296. [10.1016/S0140-6736(96)90939-3]

Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group

F. Macciardi
Penultimo
;
1996-05-11

Abstract

An association between schizophrenia and the T102C polymorphism of the gene for 5-hydroxytryptamine type 2a (5-HT2a) receptor has been reported; the proportion of allele 2 of this polymorphism is higher than expected among schizophrenic patients. We looked for an association between schizophrenia and this variant of the 5-HT2a-receptor gene in a large multicentre study.
Schizophrenia; Genotype; Polymerase Chain Reaction; Odds Ratio; Alleles; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2A; Humans; Receptors, Serotonin; Europe
Settore MED/03 - Genetica Medica
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/201428
Citazioni
  • ???jsp.display-item.citation.pmc??? 22
  • Scopus 245
  • ???jsp.display-item.citation.isi??? 229
social impact