Beta-endorphin and substance P levels were measured in the hypothalamus of rats 14 days after chronic constriction injury of right sciatic nerve. Furthermore, beta-endorphin concentrations in splenocytes, phytoemoagglutinin-induced proliferation of splenocytes, and natural killer activity were assessed. We observed a significant increase of beta-endorphin and substance P hypothalamic levels, and a significant decrease of beta-endorphin concentrations in the immune cells. In contrast, the peripheral mononeuropathy did not affect the immune function. This study presents a picture of central and peripheral peptide changes consistent with a painful condition, but different from what previously observed in rats which underwent peripheral nerve deafferentation or stressful conditions
Peripheral mononeuropathy affects hypothalamic and splenocyte beta-endorphin levels but not immune function in the rat / M. Bianchi, M.L. Sotgiu, B. Manfredi, P. Sacerdote. - In: BRAIN RESEARCH BULLETIN. - ISSN 0361-9230. - 40:4(1996), pp. 269-272.
|Titolo:||Peripheral mononeuropathy affects hypothalamic and splenocyte beta-endorphin levels but not immune function in the rat|
|Parole Chiave:||Chronic constriction injury; Hypothalamus; Sciatic ligature; Splenocyte; Substance P, Rat|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1996|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0361-9230(96)00051-2|
|Appare nelle tipologie:||01 - Articolo su periodico|