To investigate the effects of a small rise in the plasma atrial natriuretic peptide (ANP) concentration, 6 normal subjects received 2-h low dose (2 pmol/kg.min) infusions of both 28 [human alpha hANP-(99-126)]- and 26 [human ANP-(101-126)]-amino acid peptides in a placebo-controlled study. Both peptides induced more than 2-fold increases in urinary sodium, calcium, and magnesium excretion. Effective renal plasma flow was slightly reduced, glomerular filtration rate did not change, and renal filtration fraction increased during the ANP infusions. Plasma renin, angiotensin II, and aldosterone concentrations fell by about 50%. Arterial blood pressure and plasma catecholamines did not change. Hematocrit and serum albumin concentrations rose significantly. ANP effects on urinary electrolytes and the renin-angiotensin-aldosterone system were sustained for over an hour after completion of the ANP infusions. The two peptides did not differ in their effects. These results are consistent with a physiological role for plasma ANP in the regulation of extracellular fluid volume and demonstrate that minor N-terminal truncation of alpha hANP has little effect on its biological activity.
Low dose infusions of 26- and 28-amino acid human atrial natriuretic peptides in normal man / A. M. Richards, G. Tonolo, P. Montorsi, J. Finlayson, R. Fraser, G. Inglis, A. Towrie, J. J. Morton. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - 66:3(1988 Mar), pp. 465-72-472.
|Titolo:||Low dose infusions of 26- and 28-amino acid human atrial natriuretic peptides in normal man|
|Parole Chiave:||Renin; Calcium; Hydrocortisone; Humans; Phosphorus; Potassium; Angiotensin II; Regional Blood Flow; Peptide Fragments; Atrial Natriuretic Factor; Catecholamines; Creatinine; Glomerular Filtration Rate; Adult; Natriuresis; Kidney; Aldosterone; Magnesium; Male|
|Settore Scientifico Disciplinare:||Settore MED/11 - Malattie dell'Apparato Cardiovascolare|
|Data di pubblicazione:||mar-1988|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1210/jcem-66-3-465|
|Appare nelle tipologie:||01 - Articolo su periodico|