Among the different dopamine receptors, the D4 dopamine receptor is of particular interest in schizophrenia because of its high affinity for the atypical neuroleptic clozapine. Recently, the gene for the D4 dopamine receptor has been cloned and a new and intriguing polymorphism has been described. Different versions of the receptor have varying affinity for clozapine, and thus variant froms of D4 with differing pharmacologic activity exist in the human population. Our hypothesis was that these variants play a role in susceptibility to psychotic illness. Thus, our objective was to test the D4 dopamine receptor genes for linkage to schizophrenia.
|Titolo:||Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred|
MACCIARDI, FABIO (Primo)
|Parole Chiave:||Genetic Linkage; Genetic Variation; Polymorphism, Genetic; Humans; Tyrosine 3-Monooxygenase; Italy; Schizophrenia; Polymerase Chain Reaction; Receptors, Dopamine D4; Receptors, Dopamine D2; Blotting, Southern; Lod Score; Receptors, Dopamine; Family|
|Settore Scientifico Disciplinare:||Settore MED/03 - Genetica Medica|
|Data di pubblicazione:||apr-1994|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1001/archpsyc.1994.03950040032004|
|Appare nelle tipologie:||01 - Articolo su periodico|