IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishObjectives: To evaluate the effects of starting therapy with either Truvada (TVD) or Combivir (CBV) in combination with Efavirenz (EFV) or a boosted Protease Inhibitor (LPV/r, ATV/r, fAPV/r and SQV/r) on clinical, immunological, and virological parameters in HIV-infected antiretroviral (ARV) naive patients. Methods: Twenty-seven patients were prospectively enrolled and received TVD-EFV, 32 TVD-PI/r, 24 CBV-EFV, and 23 CBV-PI/r. Immunovirological analyses were performed at baseline and after 3, 6, 9 and 12 months after initiation of therapy; a full set of data is available for 51 patients. Results: Median CD4+ cell counts and HIV-RNA plasma viremia were comparable in the four groups of patients (TVD-EFV, TVD-PI/r, CBV-EFV, CBV-PI/r) at baseline. At month 12 HIV RNA plasma viremia was <50 cps/ml in all patients. Median CD4 cell counts increases were higher, although not significantly, in CBV-EFV and TVD-EFV patients. Finally, CD8+/CD38+/CDRO+T lymphocytes were significantly decreased after 12 months of therapy in all patients with, possibly, a faster effect seen in the EFV groups. Conclusions: Immunologic parameters are similarly affected by different ARV combinations, even if EFV-associated immunomodulation might be marginally better
Immune activation in HIV-infected patients treated with different ARV regimens / A. Uglietti, S. Lo Caputo, M. Lauriola, M. De Gennaro, E. Chiesa, M. Coen, R. Terzi, D.H. Bray, R. Maserati, D.L. Trabattoni, M.S. Clerici. - In: WORLD JOURNAL OF AIDS. - ISSN 2160-8814. - 2:2(2012), pp. 97-102.
| Titolo: | Immune activation in HIV-infected patients treated with different ARV regimens |
| Autori: | UGLIETTI, ALESSIA (Primo) TRABATTONI, DARIA LUCIA (Penultimo) CLERICI, MARIO SALVATORE (Ultimo) |
| Parole Chiave: | HIV ; immune activation ; antiretroviral therapy |
| Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
| Data di pubblicazione: | 2012 |
| Rivista: | |
| URL: | http://www.scirp.org/journal/PaperInformation.aspx?paperID=19731 |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.4236/wja.2012.22013 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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