The general antibacterial properties of trospectomycin (TRO) were compared with those of spectinomycin (SPEC) in an in vitro study using a collection of recent clinical isolates: 50 Gram-positive and 25 Gram-negative aerobes and 30 Gram-positive and 15 Gram-negative anaerobes. Minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined for all strains by microtitre using serial dilutions in Mueller-Hinton broth for aerobes and Brucella broth for anaerobes. The final inoculum in each well was 10(5) cfu/ml. This study shows that none of the Gram-negative organisms was sensitive to TRO; the most sensitive were streptococci aerobic strains; TRO exhibited antibiotic activity against all anaerobes tested, which was not seen with SPEC, and also exhibited bactericidal activity. The MICs of Staphylococcus epidermidis and Bacteroides fragilis tested with TRO and SPEC were not significantly affected by the size of bacterial inoculum tested, and the nature of the growth medium did not alter the susceptibility tests.

In vitro activity against aerobes and anaerobes of Trospectomycin versus Spectinomycin / M.R. Gismondo, G. Chisari, A.M. Lo Bue. - In: DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH. - ISSN 0378-6501. - 17:2(1991), pp. 101-104.

In vitro activity against aerobes and anaerobes of Trospectomycin versus Spectinomycin

M.R. Gismondo
Primo
;
1991

Abstract

The general antibacterial properties of trospectomycin (TRO) were compared with those of spectinomycin (SPEC) in an in vitro study using a collection of recent clinical isolates: 50 Gram-positive and 25 Gram-negative aerobes and 30 Gram-positive and 15 Gram-negative anaerobes. Minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined for all strains by microtitre using serial dilutions in Mueller-Hinton broth for aerobes and Brucella broth for anaerobes. The final inoculum in each well was 10(5) cfu/ml. This study shows that none of the Gram-negative organisms was sensitive to TRO; the most sensitive were streptococci aerobic strains; TRO exhibited antibiotic activity against all anaerobes tested, which was not seen with SPEC, and also exhibited bactericidal activity. The MICs of Staphylococcus epidermidis and Bacteroides fragilis tested with TRO and SPEC were not significantly affected by the size of bacterial inoculum tested, and the nature of the growth medium did not alter the susceptibility tests.
English
Settore MED/07 - Microbiologia e Microbiologia Clinica
Articolo
Comitato scientifico
1991
17
2
101
104
Pubblicato
Periodico con rilevanza internazionale
info:eu-repo/semantics/article
In vitro activity against aerobes and anaerobes of Trospectomycin versus Spectinomycin / M.R. Gismondo, G. Chisari, A.M. Lo Bue. - In: DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH. - ISSN 0378-6501. - 17:2(1991), pp. 101-104.
none
Prodotti della ricerca::01 - Articolo su periodico
3
262
Article (author)
no
M.R. Gismondo, G. Chisari, A.M. Lo Bue
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/201097
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact