Association between kanendomycin, an aminoglycoside antibiotic with a high antibacterial activity, non susceptible to inactivating action of acetylating enzymes and fosfomycin, an antimicrobial drug active only on bacterial cells, and without toxicity in man, was studied by Authors. An evidence synergism of two examined drugs was found particularly against Proteus spp. and Pseudomonas aeruginosa. A discussion about mechanisms of action of fosfomycin and kanendomycin is referred by Authors to explain this synergism.
Azione sinergica dell'associazione fosfo-kanendomicina nei confronti di germi gram-positivi e gram-negativi / G. Russo, M.A. Toscano, M.R. Gismondo, V. Nicolosi, E. Garaci. - In: ANNALI SCLAVO. - ISSN 0003-472X. - 22:1(1980), pp. 77-82.
Azione sinergica dell'associazione fosfo-kanendomicina nei confronti di germi gram-positivi e gram-negativi
M.R. Gismondo;
1980
Abstract
Association between kanendomycin, an aminoglycoside antibiotic with a high antibacterial activity, non susceptible to inactivating action of acetylating enzymes and fosfomycin, an antimicrobial drug active only on bacterial cells, and without toxicity in man, was studied by Authors. An evidence synergism of two examined drugs was found particularly against Proteus spp. and Pseudomonas aeruginosa. A discussion about mechanisms of action of fosfomycin and kanendomycin is referred by Authors to explain this synergism.Pubblicazioni consigliate
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