Calcium channels in neurons mediate a wide variety of essential functions. In addition to contributing to action potential shape, they furnish a substrate that acts as an intracellular second messenger. This study shows that the shape of the neuronal action potential has characteristics that promote long openings of L-type (high threshold) calcium channels. We also present evidence that a change in the firing rate of isolated neurons modulates gating of single calcium channels. This mechanism could be important in modulating neuron excitability and providing a rise in intracellular Ca, when needed.
Effect of firing rate on the calcium permeability in adult neurons during spontaneous action potentials / M. MAZZANTI, A. GALLI, A. FERRONI. - In: BIOPHYSICAL JOURNAL. - ISSN 0006-3495. - 63:4(1992 Oct), pp. 926-34-934. [10.1016/S0006-3495(92)81669-7]
Effect of firing rate on the calcium permeability in adult neurons during spontaneous action potentials
M. MazzantiPrimo
;
1992
Abstract
Calcium channels in neurons mediate a wide variety of essential functions. In addition to contributing to action potential shape, they furnish a substrate that acts as an intracellular second messenger. This study shows that the shape of the neuronal action potential has characteristics that promote long openings of L-type (high threshold) calcium channels. We also present evidence that a change in the firing rate of isolated neurons modulates gating of single calcium channels. This mechanism could be important in modulating neuron excitability and providing a rise in intracellular Ca, when needed.Pubblicazioni consigliate
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