The production of interleukin-2 by in vitro T helper cells in response to synthetic peptides from the envelope of HIV-1 ("peptide response") has been shown in both HIV-exposed HIV-seronegative (HIV-) and HIV-seropositive (HIV+) homosexual men. In this exploratory study, we examine the association of peptide response with sexual risk behavior and indicators of HIV disease progression in 21 HIV- and 17 HIV+ homosexual men examined in the third and fourth years of a natural history project of HIV disease in New York City. Preproject risk behaviors were associated with HIV status only. During-project risk behaviors were associated with peptide response only. There were no significant HIV Status x Peptide Response interactions. In HIV+ men, one of several disease-progression indicators also contributed. Thus, in our sample peptide response appears to reflect relatively recent exposure to HIV-1 by way of sexual risk behavior in both HIV-exposed HIV- and HIV+ men, and, in HIV+ men additionally, immunologieal impairment by disease progression.
|Titolo:||Sexual Risk Behavior May Be Associated with T-Helper-Cell Response to HIV-1 Peptides in HIV− and HIV+ Men|
CLERICI, MARIO SALVATORE (Penultimo)
|Parole Chiave:||Hiv-disease progression; Homosexual men; Interleukin-2; Sexual risk behavior; T helper cells|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||1997|
|Appare nelle tipologie:||01 - Articolo su periodico|