BACKGROUND: Evidence has been provided that high-dose indacaterol (300 μg) can reduce lung hyperinflation in moderate-to-severe chronic obstructive pulmonary disease (COPD). AIM: To study whether low-dose indacaterol (150 μg) also reduces lung hyperinflation in comparison with the recommended dose of tiotropium (18 μg) in moderate COPD. METHODS: This was a multicenter, randomized, blinded, 3-period cross-over, placebo-controlled study. Spirometry and lung volumes were measured before and 30, 60, 120, 180 and 240 min after the administration of single-doses of indacaterol, tiotropium, or placebo. The primary end-point was the change in peak inspiratory capacity (IC). The area under the 4-h curve (AUC(0-4)) for IC, 1-s forced expiratory volume (FEV(1)) and forced vital capacity (FVC) were secondary variables. RESULTS: 49 patients completed the study. On average, peak IC and AUC(0-4) for IC were significantly greater after indacaterol than placebo by 177 mL (p = 0.007) and 142 mL (p = 0.001), respectively. Differences in peak IC and AUC(0-4) for IC between tiotropium and placebo were 120 mL (p = 0.07) and 85 mL (p = 0.052), respectively. Differences between indacaterol and tiotropium were statistically insignificant. Peak IC increased by >20% in 12 patients with indacaterol and 9 with tiotropium (p = 0.001), and by >30% in 8 patients with indacaterol and 3 with tiotropium (p = 0.001). The effects of indacaterol and tiotropium on FEV(1) and FVC were statistically significant vs placebo. CONCLUSIONS: Low-dose indacaterol has a bronchodilator effect that is similar to the recommended dose of tiotropium, but it is slightly superior in reducing lung hyperinflation.
Acute effects of indacaterol on lung hyperinflation in moderate COPD : a comparison with tiotropium / A. Rossi, S. Centanni, I. Cerveri, C. Gulotta, A. Foresi, M. Cazzola, V. Brusasco. - In: RESPIRATORY MEDICINE. - ISSN 0954-6111. - 106:1(2012 Jan), pp. 84-90.
|Titolo:||Acute effects of indacaterol on lung hyperinflation in moderate COPD : a comparison with tiotropium|
CENTANNI, STEFANO (Secondo)
|Parole Chiave:||COPD; Indacaterol; Lung hyperinflation; Tiotropium|
|Settore Scientifico Disciplinare:||Settore MED/10 - Malattie dell'Apparato Respiratorio|
|Data di pubblicazione:||gen-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.rmed.2011.09.006|
|Appare nelle tipologie:||01 - Articolo su periodico|