Peripheral blood mononuclear cells (PBMC) from 40 normal individuals, 20 men and 20 women, divided according to age were evaluated for their ability to mediate natural killer (NK) cytotoxicity, using the K562 erythroleukemic cells as target. The results of a specific 51Cr release assay demonstrated that NK activity was greater in men than in women. There was a significant correlation between NK activity and the percentages of Leu 11a+ cells in younger women, but not in the other groups and no correlation between NK activity and Leu 7+ cells.
|Titolo:||Age- and sex-dependent changes in natural killer cell activity|
|Parole Chiave:||Age Factors; Immunity, Cellular; Sex Factors; Killer Cells, Natural; Humans; Leucine; Menopause; Male; Female|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||1987|
|Appare nelle tipologie:||01 - Articolo su periodico|