We have examined the allogeneic mixed lymphocyte reaction (MLR) and autologous mixed lymphocyte reaction (AMLR) stimulating activities of T cells precultured in vitro with soluble allogeneic or autologous HLA-DR antigens. These cells (Ts) are known to suppress the human MLR: this suppression is specific in that it occurs only when stimulator cells have the same HLA-DR antigen as that used to induce differentiation of suppressor cells. Ts cells express new membrane specificities; they can be separated by immunoabsorption into two populations: Ts enriched (Tx+; with suppressive activity) and Ts depleted (Ts-; with helper function). In the present study, we have demonstrated that both Ts cell subsets activated by soluble HLA-DR alloantigens are able to stimulate both MLR and AMLR. Ts cells activated by soluble autologous HLA-DR antigens are able to stimulate MLR, but not AMLR.
|Titolo:||AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens|
|Parole Chiave:||Histocompatibility Antigens Class II; T-Lymphocytes, Regulatory; Solubility; Humans; Lymphocyte Culture Test, Mixed; Lymphocyte Activation; HLA-DR5 Antigen; Cells, Cultured; HLA-DR Antigens; Adult; HLA-DR7 Antigen; Epitopes; T-Lymphocytes|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||gen-1986|
|Appare nelle tipologie:||01 - Articolo su periodico|