Previous studies of CsA-induced inhibition of alloreactivity demonstrated that there are wide interindividual variations in sensitivity to the drug. We have investigated whether or not this variability is associated with the individual HLA phenotype. We used the in vitro allogeneic mixed lymphocyte reaction (MLR) and autologous mixed lymphocyte reaction (AMLR), which are well established models for the recognition phase of allograft rejection and for cell cooperation between different lymphocyte subpopulations.
|Titolo:||In vitro effects of cyclosporine A on allogeneic and autologous lymphocyte stimulation: influence of HLA phenotypes|
SCORZA, RAFFAELLA (Primo)
|Parole Chiave:||Lymphocyte Activation; Graft Rejection; HLA-DR Antigens; Humans; Lymphocyte Culture Test, Mixed; Adult; Immunologic Memory; Lymphocyte Cooperation; HLA-D Antigens; Cyclosporins|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||apr-1988|
|Appare nelle tipologie:||01 - Articolo su periodico|