Peripheral blood lymphocytes from 15 healthy subjects, selected on the basis of their HLA types, were cultured in vitro in the presence of PHA and of a number of drugs which bind adrenergic or dopaminergic receptors (dopamine, norepinephrine, chlorpromazine, haloperidol, propranolol and apomorphine). The results obtained are consistent with an interference between HLA-A1 and cross-reacting specificities and the effect explained by these drugs on the lymphocyte activation by PHA. The possibility is suggested that HLA-A1 and cross-reacting antigens interfere with the binding of such drugs to the cell membrane receptors.
HLA antigens and the reactivity of lymphocytes to some drugs and PHA / R. Scorza-Smeraldi, M. G. Sabbadini Villa, G. Fabio, P. Bonara, M. Vanoli, L. Resele, C. Zanussi. - In: INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY. - ISSN 0192-0561. - 5:2(1983), pp. 145-9-149.
HLA antigens and the reactivity of lymphocytes to some drugs and PHA
R. Scorza-Smeraldi;G. Fabio;
1983
Abstract
Peripheral blood lymphocytes from 15 healthy subjects, selected on the basis of their HLA types, were cultured in vitro in the presence of PHA and of a number of drugs which bind adrenergic or dopaminergic receptors (dopamine, norepinephrine, chlorpromazine, haloperidol, propranolol and apomorphine). The results obtained are consistent with an interference between HLA-A1 and cross-reacting specificities and the effect explained by these drugs on the lymphocyte activation by PHA. The possibility is suggested that HLA-A1 and cross-reacting antigens interfere with the binding of such drugs to the cell membrane receptors.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.