Twenty-two patients with the Lennox-Gastaut syndrome and their families were examined for HL-A antigens by the microlymphocytotoxicity test. The antigen HL-A7 belonging to the HL-A locus showed a significantly increased frequency (p less than 0.0005) both in parents and in patients. The same antigen showed a significantly altered segregation in patients but a normal one in healthy siblings. Another antigen of the second HL-A locus, HL-A12, did not display a normal segregation in our patients, in whom it was nearly not represented.
|Titolo:||Immunogenetics of the Lennox-Gastaut syndrome: frequency of HL-A antigens and haplotypes in patients and first-degree relatives|
FABIO, GIOVANNA (Penultimo)
|Parole Chiave:||Pedigree; Histocompatibility Antigens; Immunogenetics; HLA Antigens; Gene Frequency; Haploidy; Epilepsy; Syndrome; Humans; Male; Female|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||dic-1975|
|Digital Object Identifier (DOI):||10.1111/j.1528-1157.1975.tb04754.x|
|Appare nelle tipologie:||01 - Articolo su periodico|