The bone marrow karyotype was studied in 17 patients affected by refractory anemia with excess of blasts (RAEB). A cytogenetic finding common to nearly all the cases is hypodiploidy, present in even quite high percentages. In 3 patients were identified the same interstitial deletion of the long arm of a chromosome 5, present in a percentage varying between 30% and 65%. The presence of this chromosomal anomaly appears to correspond to a slower development of the illness and transformation into acute leukemia seems rare or delayed.
|Titolo:||The bone marrow karyotype in seventeen cases of refractory anemia with excess of blasts (RAEB).|
LAVEZZI, ANNA MARIA (Primo)
|Parole Chiave:||RAEB ; cytogenetics ; hypodiploidy ; chromosome 5 ; deletion|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
Settore MED/08 - Anatomia Patologica
|Data di pubblicazione:||1983|
|Appare nelle tipologie:||01 - Articolo su periodico|