Antiphospholipid antibodies (aPL) have thrombogenic properties in vivo, through their interactions with soluble coagulation factors and their ability to modulate the functions of cells involved in coagulation homeostasis. These antibodies have also been shown to enhance the adhesion of leukocytes to endothelial cells (ECs) in vivo. New lipophilic statins such as fluvastatin have antiinflammatory and antithrombogenic effects. This study uses an in vivo mouse model to investigate whether fluvastatin has an effect on decreasing both the adhesion of leukocytes to ECs and the thrombus formation induced by aPL.
|Titolo:||Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model|
|Parole Chiave:||Administration, Oral; Animals; Fatty Acids, Monounsaturated; Intercellular Adhesion Molecule-1; Leukocytes; Disease Models, Animal; Mice; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Thrombosis; Muscle, Skeletal; Endothelium, Vascular; Mice, Inbred Strains; Indoles; Microcirculation; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Male; Cell Adhesion|
|Settore Scientifico Disciplinare:||Settore MED/16 - Reumatologia|
|Data di pubblicazione:||nov-2003|
|Digital Object Identifier (DOI):||10.1002/art.11449|
|Appare nelle tipologie:||01 - Articolo su periodico|