Calpain has been identified as a component of the biochemical pathway in programmed cell death. Calpain inhibitors are effective in preventing the progression to cell death and can restore cell function. T lymphocytes from HIV infected individuals undergo T cell receptor-triggered programmed cell death which can be treated by calpain inhibitors and immune function can be restored in affected cells. Methods for diagnosing cell populations or individuals susceptible to programmed cell death and for monitoring therapeutic effectiveness are provided

In vitro methods for assessing the susceptibility of HIV-1 infected individuals to cysteine-protease-mediated activation- induced programmed cell death / P.A. Henkart, A. Sarin, M. Clerici, G.M. Shearer.

In vitro methods for assessing the susceptibility of HIV-1 infected individuals to cysteine-protease-mediated activation- induced programmed cell death

M. Clerici
Penultimo
;
1997

Abstract

Calpain has been identified as a component of the biochemical pathway in programmed cell death. Calpain inhibitors are effective in preventing the progression to cell death and can restore cell function. T lymphocytes from HIV infected individuals undergo T cell receptor-triggered programmed cell death which can be treated by calpain inhibitors and immune function can be restored in affected cells. Methods for diagnosing cell populations or individuals susceptible to programmed cell death and for monitoring therapeutic effectiveness are provided
The United States Of America As Represented By The Department Of Health And Human Services
US5607831
US37,578
4-mar-1997
Settore MED/04 - Patologia Generale
In vitro methods for assessing the susceptibility of HIV-1 infected individuals to cysteine-protease-mediated activation- induced programmed cell death / P.A. Henkart, A. Sarin, M. Clerici, G.M. Shearer.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/199996
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